Hemp Flower Extract + Anxiety Info

Hemp Flower Extract Has Unique Ability to Cross Blood-Brain Barrier

by Dr. Joseph Mercola

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Story at-a-glance

• Your body has a barrier to keep foreign chemicals from accessing your brain and spinal cord. Researchers have discovered by coating nanocapsules with Hemp Flower Extract, they could carry particles into the brain of mice
• Hemp Flower Extract is the nonpsychoactive component of cannabis, which has strong anti-anxiety effects. Its ability to cross the blood-brain barrier suggests your brain has cannabinoid receptors used to maintain health
• Although it’s normal to be concerned, too much stress and anxiety steals your time, energy and health; according to the World Health Organization, by 2030 global costs of anxiety treatment are expected to reach $147 billion annually
• Low levels of endocannabinoids impact your risk of migraines, fibroids, irritable bowel syndrome and neurological conditions, but using Hemp Flower Extract alone is not the answer to support your endocannabinoid system (ECS)
• Natural ways to boost your ECS include avoiding pesticides, optimizing omega-3 intake, fasting, exercise and reducing stress
• The cannabis plant has over 400 chemicals and at least 60 different cannabinoids¹ — chemical compounds the human body is uniquely equipped to respond to. Of the two primary chemicals, cannabidiol and tetrahydrocannabinol, only the later has psychoactive properties.
• THC is the compound in cannabis triggering a "high," whereas Hemp Flower Extract has no psychoactive effects. Both compounds, and other phytochemicals found in medical marijuana plants, have a long list of beneficial effects on health.
• Medical marijuana is a term used for the use of the whole, unprocessed plant or its chemicals to treat a medical condition.^2,3 With the exception of four cannabis-containing or cannabis-related products for specific conditions with a prescription, the U.S. Food and Drug Administration has not approved any "marketing application for cannabis for the treatment of any disease or condition."⁴ On the other hand, some states have gone ahead and approved it themselves for certain medical conditions.⁵
• The number of states that have decriminalized, legalized or allowed medical marijuana sales continues to grow. In some states, cannabis is fully legal or illegal, but in others the laws are mixed, allowing medicinal use but not recreational.⁶
• According to the National Institute on Drug Abuse,⁷ notable scientific study results led to the creation of two FDA-approved medications containing cannabinoid chemicals in pill form, but not the use of the whole plant. Recently scientists proved Hemp Flower Extract can carry other chemicals across the blood brain barrier, opening up its medicinal potential even further.

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The Blood-Brain Barrier Is Designed to Protect Your Brain

• More than 100 years ago, scientists discovered not everything injected into the bloodstream would reach the brain or spinal cord.⁸ Through research, scientists discovered the blood-brain barrier is semi permeable; in other words, it allows some materials to cross into your neurological system, but prevents others.
• The importance of the blood-brain barrier to the health of your neurological system cannot be overstated. One portion of the system is formed by endothelial cells lining the microvasculature, which feeds your brain. This protects it from circulating agents and substances capable of disturbing your neurological functioning.⁹
• The endothelial tissue in other capillaries in your body have small spaces allowing substances to move between the inside and outside of the vessel. In the brain, these cells fit together so tightly that many substances cannot leave the bloodstream and enter the brain.¹⁰
• Additionally, glial cells — astrocytes — form another layer around the blood vessels and are involved in a two-way communication affecting physiology and pathology.¹¹ This barrier mechanism is vital for normal functioning and providing a stable internal environment. One compound known to normally pass the blood-brain barrier is Hemp Flower Extract.

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 Pharmaceutical Industry Finds Way to Use Hemp Flower Extract as a Trojan Horse

• In Greek mythology, the Trojan War was fought between the Greeks and the city of Troy.¹² To gain access, the Greeks used a massive wooden horse constructed to hide a select force of men. It was presented as a gift, thereby allowing the Greek warriors to enter and destroy the city. Researchers believe Hemp Flower Extract can act as a Trojan horse, helping move restricted chemicals across the blood-brain barrier.¹³
• Researchers were interested in using Hemp Flower Extract as a means to an end. They attached Hemp Flower Extract, resembling endocannabinoids made by both mice and humans, to the outside of nanocapsules loaded with fluorescent molecules.
• The fluorescence enabled the researchers to track the particles with the hope the experiment would mimic what occurs in the blood-brain barrier of humans. They demonstrated the Hemp Flower Extract nanocarriers could transport fluorescent molecules across the blood-brain barrier in mice.¹⁴
• When added in vitro to human cells mimicking the blood-brain barrier, the nanocarriers with Hemp Flower Extract were more successful in passing through the cells than those without it Researchers also found when Hemp Flower Extract nanocapsules were injected into healthy mice, 2.5 times more of them entered the animals' brains than nanocarriers of equal size lacking the Hemp Flower Extract coating.

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 The Nonpsychoactive Component Has Anti-Anxiety Effects

• The ability of Hemp Flower Extract to naturally move across the blood-brain barrier indicates there are endocannabinoid receptors in the brain, which your neurological system uses to maintain optimal health. One of the benefits of Hemp Flower Extract on your neurological system is reducing anxiety.
• A meta-analysis¹⁵ evaluated the potential for Hemp Flower Extract as a treatment for anxiety-related disorders. They found preclinical evidence strongly supported it for the treatment for panic disorder, social anxiety disorder, obsessive-compulsive disorder and post-traumatic stress disorder (PTSD).
• A second large retrospective study¹⁶ looked at cases in psychiatric clinics involving the application of Hemp Flower Extract for anxiety and sleep complaints. It too found the data supported the use of Hemp Flower Extract for anxiety-related disorders.
• In a small study¹⁷ involving 24 patients with generalized social anxiety disorder who, while diagnosed, had never been treated, half received Hemp Flower Extract while the other half received a placebo. Another 12 healthy control subjects performed the test without receiving either medication or a placebo.
• Each volunteer participated in a double-blind procedure. The researchers compared the effects of a simulation of public speaking on the 36 individuals, finding Hemp Flower Extract pretreatment significantly affected cognitive impairment, anxiety and discomfort in speech performance.
• The participants in the placebo group experienced higher anxiety, cognitive impairment and alert levels than the control group. No significant differences were observed between those taking Hemp Flower Extract and the healthy control subjects who took nothing.¹⁸
• These results piqued the interest of Dr. Esther Blessing, psychiatrist and researcher at New York University. She obtained funding from the National Institutes of Health, and along with collaborators are beginning a clinical trial to test if Hemp Flower Extract helps those with PTSD and moderate or severe alcohol use disorder.¹⁹
• The researchers plan to use pharmaceutical grade Hemp Flower Extract or a placebo daily on 50 participants with the goal of evaluating alcohol intake in those who take Hem[ Flower Extract.
• A second study²⁰ now in Phase II is exploring whether Hemp Flower Extract may help prevent relapse in opioid addicts. As explained by Blessing, Hemp Flower Extract is different from cannabis. Although it's extracted from cannabis, it does not lead to altered perception or cognition.²¹ She commented:²²
• "Drugs can be non-psychoactive and still have an effect on the brain. Hemp Flower Extract does have an effect on the brain, but it seems to affect the brain in possibly medicinal ways."

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 Anxiety Steals Time, Energy and Lives

• Although it's normal to be concerned about aspects of your life, too much stress and worry may devastate your health. A rise in stress levels and anxiety may trigger physical, mental or emotion changes, an indicator of anxiety disorders.²³ Anxiety disorders are among the most common mental illnesses in the U.S., affecting an estimated 40 million adults.
• Those suffering are three to five times more likely to see their physician and six times more likely to be hospitalized. It's not uncommon for someone with anxiety to also suffer depression.²⁴ Anxiety disorders carry a significant financial burden to individuals, families and communities.
• According to the World Health Organization (WHO), by 2030, the global annual cost of anxiety will reach $147 billion.²⁵ Researchers in one study concluded:²⁶
• "The cost burden of depression, anxiety, and emotional disorders is among the greatest of any disease conditions in the workforce. It is worth considering methods for quantifying direct and indirect costs that use administrative data sources given their utility."
• The cost of anxiety is measured in more than finances, as it takes an enormous emotional and physical toll. Long-term negative health effects may include digestive issues, insomnia, substance abuse disorders and depression,²⁷ each of which come with a laundry list of physical symptoms, emotional disruption and financial burden.

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Differences Between Recreational and Medicinal Use

• The healing properties of medical cannabis come primarily from high levels of Hemp Flower Extract and critical levels of other medicinal terpenes and flavonoids. However, THC, responsible for the psychoactive effects of cannabis, also has medicinal benefits.^28,29 Growers are able to use selective breeding techniques to increase Hemp Flower Extract and lower levels of THC for medicinal use.
• While Hemp Flower Extract has gained the most attention, Hemp Flower Extract alone cannot fully support your body's endocannabinoid system (ECS). Cannabinoid receptors in the human body were discovered in the 1990s,³⁰ which in turn led to the realization our body makes endogenous cannabinoids that influence these receptors.
• It was also discovered the ECS orchestrates communication between other bodily systems, such as your respiratory, digestive, immune and cardiovascular systems. The ECS does this via receptors found in every organ, including your skin. The use of medicinal Hemp Flower Extract is aimed at the health benefits derived from providing your ECS with sufficient support.
• However, if you choose to use exogenous Hemp Flower Extract, it's important to choose the right product as some do not meet the claims made on the label.³¹ Since Hemp Flower Extract became a focus of popular holistic medicine almost overnight, the rapid innovations in the market have been impressive. However, while products quickly enter the market, effective control has not caught up yet.
• Despite Hemp Flower Extract being sold as a food supplement, it is often used for significant health problems. The WHO analyzed available scientific data and concluded Hemp Flower Extract does not require drug scheduling. Nevertheless, Hemp Flower Extract manufacturing may benefit from a preparation analysis to reduce contaminants and ensure the product in the bottle is what's on the label.³²
• Researchers believe the methodology to achieve this goal already exists and the approach would hold the producer accountable for quality and safety. Until a system is in place, if you live in a state that has legalized Hemp Flower Extract, it is important you purchase any products from a trusted source.

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 Single Magic Bullet Is Not the Answer to Support Your Endocannabinoid System

• In this video clip from an interview with Carl Germano, board-certified nutritionist and phytocannabiniods expert, he discusses the need to move away from the single magic bullet idea of separating one nutritional compound from a plant and expecting miraculous results.
• It's important in many cases to consume the whole plant. The cannabis plant contains at least 60 other cannabinoids and 400 other chemicals, and many of these other phytocannabinoids and terpenes are needed to fully support your ECS.
• However, the vilification of cannabis continues to negatively impact the ability to use the compounds medicinally.³³ Hemp Flower Extract has demonstrated use in the treatment of pain,³⁴ which represents a significant threat to the sale of opioids responsible for a large piece of the financial growth of Big Pharma in the past decade.³⁵
• Purdue Pharma went even further, trying to position the company as an "end-to-end provider" of opioids and the treatment for addiction.³⁶ The cannabis plant also poses economic threats³⁷ to the lumber, energy, food and other industries as the fiber may be used to make paper, biofuel, building materials, food products and oil, clothing, shoes and even jewelry.

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 Cannabinoids Necessary for Optimal Health

• Low levels of endocannabinoids in your system result in ill health. As you age, your body becomes less efficient in creating endocannabinoids needed for optimal health. According to Germano, cannabinoids may be used as biological markers for specific conditions and illnesses.
• Endocannabinoid deficiency has been identified in those with migraines, fibromyalgia, irritable bowel syndrome and neurological conditions, for example. Research has also discovered an intimate relationship between ECS and your omega-3 status, as omega-3 fat improves your cannabinoid receptors.
• Other conditions associated with low levels include stress, anxiety, insomnia and eye health. For a long list of health benefits you'll receive from supporting your ECS system, see my previous article, "The Many Medicinal Benefits of Cannabis and Cannabidiol."

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 How to Boost Your Natural Endocannabinoid Levels

• In my previous article, "The Endocannabinoid System and the Important Role It Plays in Human Health," I discussed the importance of activating your ECS. There are several natural ways you may activate the system to improve your health without using external cannabinoids:

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